CYP51/PD-L1-IN-1

Overview

CYP51/PD-L1-IN-1 (compound L11) is a quinazoline compound with antifungal activity. CYP51/PD-L1-IN-1 is a dual inhibitor of CYP51 ( IC 50 : 0.884 μM) and PD-L1 ( IC 50 : 0.083 μM), which can induce early apoptosis of fungal cells in the cell cycle. CYP51/PD-L1-IN-1 also significantly reduced intracellular IL-2 , NLRP3 , and NF-κBp65 protein levels, induced mitochondrial damage and ROS accumulation, and ultimately led to fungal lysis and death.

Application

Products | Products > Disease Areas > Infection | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Infection | Products > Signaling Pathways > Fungal | Products > Signaling Pathways > PD-1/PD-L1 | Products > Signaling Pathways > Cytochrome P450

Product Information

• Catalog No.: HY-156149
• CAS No.: 3032386-49-2
• Molecular Formula: C20H15N5O2
• Molecular Weight: 357.37
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source