MK-7622

Overview

MK-7622 (M1 receptor modulator) is an orally active positive allosteric modulator of muscarinic M1 acetylcholine receptors ( mAChRs ). MK-7622 enhances ACh-induced calcium flux in CHO cells expressing human M1 receptors ( EC 50 = 21 nM) and shows robust agonist activity in rat M1-expressing CHO cells, increasing intracellular calcium . MK-7622 reverses Scopolamine (HY-N0296)-induced cognitive deficits in rhesus macaques in an object retrieval detour task. MK-7622 can be used for the study of Alzheimer's disease (AD).

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Alzheimer's Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > mAChR | Products > Signaling Pathways > Calcium Channel

Product Information

• Catalog No.: HY-15618
• CAS No.: 1227923-29-6
• Molecular Formula: C25H25N3O2
• Molecular Weight: 399.48
• Purity: 99.80%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (6.26 mM); Clear solution
• Availability: In-stock

Source

Original product source