NMS-P528

Overview

NMS-P528 is a DNA minor groove alkylating agent and ADC payload . NMS-P528 undergoes intramolecular cyclization to form reactive electrophilic derivatives, which in turn induce DNA damage, cell cycle arrest, and Apoptosis . NMS-P528 shows no significant anti-tumor activity as a free payload in a HER2 -negative Raji lymphoma mouse xenograft model. NMS-P528 serves as the cytotoxic payload for the antibody-drug conjugate EV20/NMS-P945. NMS-P528 can be used in research related to breast cancer , gastric cancer , colon adenocarcinoma, Burkitt's lymphoma, neuroblastoma, pancreatic cancer , prostate cancer , head and neck cancer , ovarian cancer , and melanoma.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Prostate Cancer | Products > Disease Areas > Urogenital Cancer | Products > Disease Areas > Gastric Cancer | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Pancreatic Cancer | Products > Disease Areas > Melanoma | Products > Disease Areas > Ovarian Cancer | Products > Disease Areas > Neuroblastoma | Products > Disease Areas > CNS Neoplasm | Products > Disease Areas > Cancer | Products > Signaling Pathways > Antibody-Drug Conjugate/ADC Related | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Neurological Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > ADC Payloads | Products > Signaling Pathways > DNA/RNA Synthesis | Products > Signaling Pathways > DNA Alkylator/Crosslinker | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-156249
• CAS No.: 1466546-45-1
• Molecular Formula: C27H28ClN3O3S
• Molecular Weight: 510.05
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source