D359-0396

Overview

D359-0396 is an orally active NLRP3 inflammasome inhibitor. D359-0396 inhibits pyroptosis and IL-1β release in macrophages. D359-0396 also inhibits the oligomerization of NLRP3 , ASC and the cleavage of GSDMD. D359-0396 alleviates EAE, and also improves survival after septic shock in mice.

Application

Products | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Depression | Products > Disease Areas > Pain | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > NOD-like Receptor (NLR) | Products > Signaling Pathways > Pyroptosis

Product Information

• Catalog No.: HY-156374
• CAS No.: 1031977-31-7
• Molecular Formula: C24H24N4O2
• Molecular Weight: 400.47
• Purity: 99.98%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source