MN551

Overview

MN551 is a covalent modulator of SOCS2 and CISH , with selectivity for SOCS2 and CISH over SOCS4 . MN551 covalently modifies Cys111 in the SH2 domain of SOCS2 and Cys144 in the EF loop of the CISH SH2 domain, while only minimally modifying Cys471 in the BG loop of the SOCS6 SH2 domain. MN551 increases the thermal stability of the recombinant SOCS2-ElonginB-ElonginC complex and competitively blocks the binding of SOCS2 to its substrate; when delivered via the prodrug MN714, it blocks the intracellular recruitment of substrates by SOCS2. MN551 can serve as a chemical probe for investigating the biological functions of SOCS2 and its CRL5 complex, and also act as an E3 ligase-binding module in proteolysis-targeting chimeras ( PROTACs ).

Application

Products | Products > Disease Areas > Others | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Others | Products > Signaling Pathways > E1/E2/E3 Enzyme

Product Information

• Catalog No.: HY-156395
• CAS No.: 3044099-90-0
• Molecular Formula: C26H26ClFN3O7P
• Molecular Weight: 577.93
• Purity: 98.01%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (4.33 mM); Clear solution
• Availability: In-stock

Source

Original product source