PROTAC BRD4 Degrader-21

Overview

PROTAC BRD4 Degrader-21 is a BRD4 -targeting PROTAC degrader with an IC 50 value of 59 nM. PROTAC BRD4 Degrader-21 induces ubiquitination of BRD4 , leading to its degradation via the proteasome . PROTAC BRD4 Degrader-21 binds to recombinant HSP90α protein with moderate affinity, having an IC 50 of 100-1000 nM. PROTAC BRD4 Degrader-21 induces cancer cell death. PROTAC BRD4 Degrader-21 inhibits tumor growth in xenograft mouse models. PROTAC BRD4 Degrader-21 can be used for the research of acute myeloid leukemia, diffuse large B-cell lymphoma. (Pink: BRD4 ligand ( HY-78695 ); Blue: MDM2 E3 ligase ligand; Black: linker).

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Acute Myeloid Leukemia | Products > Disease Areas > Diffuse Large B-cell Lymphoma | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Epigenetic Reader Domain | Products > Signaling Pathways > HSP

Product Information

• Catalog No.: HY-156566
• CAS No.: 2503036-46-0
• Molecular Formula: C47H54Cl2N10O4S
• Molecular Weight: 925.97
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source