SMD-3040 is a potent and selective SMARCA2 PROTAC degrader ( DC 50 : 12 nM; D max : 91%). SMD-3040 can inhibit tumor cell proliferation and exhibits antitumor activity. SMD-3040 can be used in the study of tumors such as melanoma. (Pink: SMARCA2 ligand ( HY-171765 ); Blue: VHL ligand ( HY-112078 ); Black: linker).
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