N-Methylhistamine dihydrochloride

Overview

N-Methylhistamine dihydrochloride (Nα-Methylhistamine dihydrochloride) is a non-selective Histamine receptor agonist. N-Methylhistamine dihydrochloride activates histamine H 1 , H 2 and H 3 receptors; it stimulates central H 1 receptors by activating sympathetic α and β adrenergic receptors to inhibit intestinal transit, exerts dose-dependent inhibition on intestinal transit, reduces histamine turnover in mouse brains, and increases gastric acid secretion without altering plasma gastrin concentrations. N-Methylhistamine dihydrochloride produces a pH-dependent, voltage-independent potentiating effect on acid-sensing ion channel 1a, and shows no significant activity toward homologous ASIC2a channels. N-Methylhistamine dihydrochloride can be used in studies related to Helicobacter pylori infection .

Application

Products | Products > Disease Areas > Gastric Disease | Products > Disease Areas > Bacterial Infection | Products > Disease Areas > Helicobacter Pylori Infection | Products > Disease Areas > Infection | Products > Disease Areas > Digestive System Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Infection | Products > Signaling Pathways > Histamine Receptor | Products > Signaling Pathways > Sodium Channel

Product Information

• Catalog No.: HY-101005
• CAS No.: 16503-22-3
• Molecular Formula: C6H13Cl2N3
• Molecular Weight: 198.09
• Purity: 99.99%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Availability: In-stock

Source

Original product source