Egalognastat

Overview

Egalognastat (ASN90) is a selective, brain-penetrant and orally active O-GlcNAcase ( OGA ) enzyme inhibitor with an IC 50 value of 10.2 nM. Egalognastat increases O-GlcNAcylation of intracellular proteins like tau and α-synuclein , preventing their aggregation and toxicity. Egalognastat does not inhibit hexosaminidase (Hex). Egalognastat can be used for the research of neurodegenerative diseases, such as tauopathies and α-synucleinopathies (e.g., Alzheimer’s disease and Parkinson’s disease).

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Alzheimer's Disease | Products > Disease Areas > Parkinson's Disease | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > OGA | Products > Signaling Pathways > Tau Protein

Product Information

• Catalog No.: HY-156586
• CAS No.: 1884154-02-2
• Molecular Formula: C17H21N5O3S
• Molecular Weight: 375.45
• Purity: 99.03%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 2.5 mg/mL (6.66 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source