PROTAC MLKL Degrader-1

Overview

PROTAC MLKL Degrader-1 is a selective MLKL PROTAC degrader with a DC 50 of 2.4 μM. PROTAC MLKL Degrader-1 blocks necroptosis without modulating the phosphorylation of RIPK1 or RIPK3 , and exhibits a linear correlation between MLKL levels and necroptotic cell death. (Pink: Mixed Lineage Kinase ligand ( HY-175705 ); Blue: Cereblon ligand ( HY-W249500 ); Black: linker).

Application

Products | Products > Disease Areas > Others | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Others | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Mixed Lineage Kinase | Products > Signaling Pathways > Necroptosis

Product Information

• Catalog No.: HY-156591
• CAS No.: 3032600-90-8
• Molecular Formula: C46H55F2N9O9S
• Molecular Weight: 948.05
• Purity: 99.76%
• Storage: 4°C, protect from light, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
• Availability: In-stock

Source

Original product source