S3226

Overview

S3226 is a highly selective NHE-3 inhibitor ( IC 50 <1 μM) that specifically blocks NHE-3 -mediated sodium transport. S3226 significantly inhibits blastocyst formation and expansion in mouse embryos, and reduces fluid and electrolyte reabsorption in rat proximal tubules in a dose-dependent manner. S3226 effectively alleviates ischemia-induced acute renal failure by improving renal function parameters, reducing renal tubular injury and restoring intracellular pH homeostasis, without interfering with the normal tubuloglomerular feedback response. S3226 is widely used in studies of acute renal failure and related pathological mechanisms.

Application

Products | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Renal Disease | Products > Disease Areas > Renal Failure | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > Na+/H+ Exchanger (NHE)

Product Information

• Catalog No.: HY-156696
• CAS No.: 215183-03-2
• Molecular Formula: C17H24Cl2N6O2
• Molecular Weight: 415.32
• Purity: 99.65%
• Storage: 4°C, stored under nitrogen, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
• Availability: In-stock

Source

Original product source