PROTAC DDa-1

Overview

PROTAC DDa-1 is a multi-targeted DCAF1-recruiting tyrosine kinase PROTAC degrader. PROTAC DDa-1 mediates the degradation of TNK2 , CSK , LIMK2 , TEC , and BTK , with a DC 50 of 90 nM for BTK . PROTAC DDa-1 reduces the viability of BTK-dependent diffuse large B-cell lymphoma cells. PROTAC DDa-1 can be used for the research of diffuse large B-cell lymphoma. (Pink: Bcr-Abl and Btk and Src ligand ( HY-107447 ); Blue: Cereblon ligand ( HY-149934 ); Black: linker).

Application

Products | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Btk | Products > Signaling Pathways > Src | Products > Signaling Pathways > Bcr-Abl

Product Information

• Catalog No.: HY-156745
• CAS No.: 3036944-98-3
• Molecular Formula: C60H77Cl2N13O3S
• Molecular Weight: 1131.31
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source