LY 367265

Overview

LY 367265 is a 5-hydroxytryptamine transporter ( SERT ) inhibitor ( IC₅₀ = 3.1 nM) and a 5-HT₂A receptor antagonist ( K ᵢ = 0.81 nM). LY 367265 has the inhibitory activity on the norepinephrine transporter ( NET ) of extremely weak ( IC₅₀ > 1000 nM); it has low affinity for subtypes such as 5-HT₁B ( Kᵢ = 490 nM) and 5-HT₁D ( Kᵢ = 81 nM), showing high selectivity. LY 367265 concentration-dependently enhances of [³H]5-HT efflux ( EC₅₀ = 250 nM). LY 367265 antagonizes the contraction response of Sumatriptan ( HY-B0121B ), indicating its functional antagonistic activity on 5-HT₁D-like receptors. LY 367265 can be used for the study of diseases such as anxiety disorders and post-traumatic stress disorder.

Application

Products | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Serotonin Transporter | Products > Signaling Pathways > 5-HT Receptor

Product Information

• Catalog No.: HY-156807
• CAS No.: 210751-39-6
• Molecular Formula: C24H25FN4O2S
• Molecular Weight: 452.54
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source