YL-365

Overview

YL-365 is a potent and selective GPR34 antagonist with an IC 50 of 17 nM. YL-365 binds to a portion of the orthosteric binding pocket of GPR34 and induces allosteric changes that stabilize the receptor in an inactive conformation. YL-365 down-regulates expression of the proinflammatory gene iNOS in M1 microglia and suppresses proinflammatory responses. YL-365 reduces mechanical allodynia in a dose-dependent manner in a mouse model of neuropathic pain. YL-365 can be used for the research of neuropathic pain.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Orphan GPCR

Product Information

• Catalog No.: HY-156815
• CAS No.: 3077715-58-0
• Molecular Formula: C34H31ClN2O5
• Molecular Weight: 583.07
• Purity: 99.96%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: 5 mg/mL (8.58 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source