PF-04455242

Overview

PF-04455242 is an orally bioavailable, blood-brain barrier-permeable κ-opioid receptor ( KOR ) inhibitor. PF-04455242 blocks in vivo effects induced by KOR and MOR agonists, and elicits KOR -independent outward currents in ventral tegmental area neurons. PF-04455242 promotes energy expenditure and activates the hypothalamic mTOR pathway. PF-04455242 attenuates stress-induced behavioral effects and produces antidepressant-like effects. PF-04455242 can be used in studies related to pain, depression, addictive disorders, and obesity induced by estrogen withdrawal.

Application

Products | Products > Disease Areas > Depression | Products > Disease Areas > Pain | Products > Disease Areas > Obesity | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Lipid Metabolism | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Research Areas > Neurological Disease | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > Opioid Receptor | Products > Signaling Pathways > mTOR

Product Information

• Catalog No.: HY-15691
• CAS No.: 1202647-54-8
• Molecular Formula: C21H28N2O2S
• Molecular Weight: 372.52
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source