Tyrosine kinase-IN-7 (compound 13h) is an inhibitor of the tyrosine kinase EGFR . The IC 50 s for inhibiting EGFR (WT) and EGFR (T790M) are 0.630 μM and 0.956 μM respectively. Tyrosine kinase-IN-7 has antitumor activity against four cancer cell lines (HepG2, HCT-116, MCF-7, and A431) with IC 50 s of 13.02 μM, 10.14 μM, 12.68 μM, and 47.05 μM, respectively.
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