TRPV2-selective blocker 1

Overview

TRPV2-selective blocker 1 is a TRPV2 -selective blocker that inhibits calcium influx and ionic currents. TRPV2-selective blocker 1 exhibits an IC 50 of 6.3 μM against rat TRPV2 , and shows no activity against TRPV1 , TRPV3 or TRPV4 channels. TRPV2-selective blocker 1 attenuates macrophage phagocytosis, LPS-induced macrophage migration, and calcium microdomains generated by peripheral TRPV2 . TRPV2-selective blocker 1 is non-cytotoxic and can be used to investigate the function of TRPV2 during immune processes.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Pain | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > TRP Channel

Product Information

• Catalog No.: HY-157131
• CAS No.: 2242724-49-6
• Molecular Formula: C15H18OS2
• Molecular Weight: 278.43
• Purity: 99.84%
• Storage: -20°C, protect from light, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
• Solubility: ≥ 0.83 mg/mL (2.98 mM); Clear solution
• Availability: In-stock

Source

Original product source