MAT-POS-e194df51-1 is an orally active, non-covalent and non-peptide SARS-CoV-2 main protease (M pro ) inhibitor with an IC 50 value of 37nM. MAT-POS-e194df51-1 is cytotoxic with EC 50 values of 64 nM and 126 nM in A549-ACE2-TMPRSS2 cells and HeLa -ACE2 cells, respectively.
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