ACBI3

Overview

ACBI3 (compound 7), a chemical probe, is a PROTAC targeting KRAS . ACBI3 achieves in vivo degradation of oncogenic KRAS, resulting in durable pathway modulation and tumor regressions in KRAS mutant xenograft mouse models. (Pink: K-Ras WT ligand ( HY-162960 ); Blue: VHL ligand ( HY-401613 ); Black: linker ( HY-169992 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Ras

Product Information

• Catalog No.: HY-157228
• CAS No.: 2938169-76-5
• Molecular Formula: C50H62N14O6S2
• Molecular Weight: 1019.25
• Purity: 99.47%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source