GLPG3312

Overview

GLPG3312 (Compound 28) is an orally active SIK inhibitor with IC 50 values of 2.0 nM, 0.7 nM and 0.6 nM for SIK1 , SIK2 and SIK3 , respectively. GLPG3312 exhibits anti-inflammatory and immunomodulatory activity in vitro on human primary myeloid cells and in vivo in mouse models. GLPG3312 has good oral bioavailability and can be used for research on inflammatory and immune diseases.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > TGF-beta/Smad | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > RIP kinase | Products > Signaling Pathways > LIM Kinase (LIMK) | Products > Signaling Pathways > MAP3K | Products > Signaling Pathways > Bcr-Abl | Products > Signaling Pathways > Src | Products > Signaling Pathways > TGF-β Receptor | Products > Signaling Pathways > Salt-inducible Kinase (SIK) | Products > Signaling Pathways > Discoidin Domain Receptor

Product Information

• Catalog No.: HY-157442
• CAS No.: 2340388-72-7
• Molecular Formula: C23H21F2N5O3
• Molecular Weight: 453.44
• Purity: 98.63%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 2.5 mg/mL (5.51 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source