PPADS tetrasodiuma is a non-selective P2X receptor antagonist. PPADS tetrasodiuma blocks recombinant P2X1, -2, -3, -5 with IC 50 s ranging from 1 to 2.6 μM. PPADS tetrasodiuma blocks native P2Y2-like ( IC 50 ~0.9 mM) and recombinant P2Y4 ( IC 50 ~15 mM) receptors. PPADS tetrasodiuma is an inhibitor of the reverse mode of the Na/Ca 2+ exchanger in guinea pig airway smooth muscle.
Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > P2X Receptor | Products > Signaling Pathways > Na+/Ca2+ Exchanger
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