PROTAC SARS-CoV-2 Mpro degrader-1

Overview

PROTAC SARS-CoV-2 Mpro degrader-1 is a SARS-CoV-2 M pro PROTAC degrader with a DC 50 of 18.1 μM. PROTAC SARS-CoV-2 Mpro degrader-1 recruits the Von-Hippel Lindau (VHL) E3 ligase to mediate ubiquitination and proteasomal degradation of SARS-CoV-2 M pro , without inhibiting the catalytic activity of M pro . PROTAC SARS-CoV-2 Mpro degrader-1 exhibits broad-spectrum antiviral activity against coronaviruses ( SARS-CoV-2 , HCoV-OC43 , HCoV-229E ). PROTAC SARS-CoV-2 Mpro degrader-1 can be used in studies related to SARS-CoV-2 infection , HCoV-OC43 infection , and HCoV-229E infection . (Pink: SARS-CoV-2 Mpro ligand ( HY-14397 ); Blue: VHL ligand ( HY-112078 ); Black: linker).

Application

Products | Products > Disease Areas > hCoV-OC43 | Products > Disease Areas > SARS-CoV-2 Infection | Products > Disease Areas > Infection | Products > Disease Areas > Coronavirus Infection | Products > Disease Areas > hCoV-229E | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > SARS-CoV | Products > Signaling Pathways > Virus Protease

Product Information

• Catalog No.: HY-157804
• CAS No.: 3029579-46-9
• Molecular Formula: C52H63ClN8O8S
• Molecular Weight: 995.62
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source