PROTAC α-Synuclein/Tau degrader 1

Overview

PROTAC α-Synuclein/Tau degrader 1 is a blood-brain barrier-penetrant dual PROTAC degrader of α-synuclein ( α-Syn ) and tau , with DC 50 of 1.57 μM and 4.09 μM, respectively. PROTAC α-Synuclein/Tau degrader 1 binds to α-Syn and tau PFF, with K D s of 0.47 and 2.78 μM, respectively. PROTAC α-Synuclein/Tau degrader 1 exhibits degradation effect mediated by the ubiquitin-proteasome system (UPS). PROTAC α-Synuclein/Tau degrader 6 can be used for the study of Parkinson’s disease (PD) (Pink: α-Synuclein/Tau ligand ( HY-151035 ); Blue: CRBN ligase ligand ( HY-14658 ); Black: Linker ( HY-128803 )). (Pink: Tau Protein and α-synuclein ligand ( HY-151035 ); Blue: Cereblon ligand ( HY-14658 ); Black: linker ( HY-128803 )).

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Parkinson's Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > α-synuclein | Products > Signaling Pathways > Tau Protein

Product Information

• Catalog No.: HY-157839
• CAS No.: 3032208-24-2
• Molecular Formula: C37H39N5O9S
• Molecular Weight: 729.80
• Purity: 99.28%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source