Anti-infective agent 9 (compound 1) is a Plasmodium falciparum inhibitor ( IC 50 =600 nM), can downregulate pyruvate levels and TCA cycle in Plasmodium . Anti-infective agent 9It has good metabolic stability and low toxicity to human liver cells. The study found, Anti-infective agent 9Potential targets for inhibiting Plasmodium falciparum are not 1-deoxidation-d-xylulose-5-Phosphate synthase (DXPS).
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