JJC8-089 is a dopamine transporter (DAT) inhibitor that may improve motivational dysfunction and increase effortful behavior in goal-directed activities. JJC8-089 significantly reversed the low-effort effects induced by the VMAT-2 inhibitor Tetrabenazine ( HY-B0590 ) in rats and increased the choice of high-effort fixed-ratio 5-bar presses versus food intake. .
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