NST-628

Overview

NST-628 is a brain-permeable MAPK pathway molecule glue that inhibits RAF phosphorylation and MEK activation. NST-628 also binds RAF and prevents the formation of BRAF-CRAF and BRAF-ARAF heterodimers, effectively inhibiting the RAS-MAPK pathway. NST-628 inhibits RAS- and RAF-driven cancers and demonstrated potent inhibition in mutant KRAS, NRAS, BRAF class II/III, and NF1-mutant tumors.

Application

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Product Information

• Catalog No.: HY-158115
• CAS No.: 3002056-30-3
• Molecular Formula: C22H18F2N4O5S
• Molecular Weight: 488.46
• Purity: 99.35%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (10.24 mM); Clear solution
• Availability: In-stock

Source

Original product source