BTL-MK (Compound 19) an orally active antiallergic agent, that inhibits degranulation of mast cells with an IC 50 of 6.7 μM, through binding to the inhibitory receptor FcγRIIB . BTL-MK improves the metaboilic stability in human liver microsomes. BTL-MK ameliorates the allergic response in Ovalbumin, low endotoxin ( HY-W250978A )-induced food allergy mice model. BTL-MK exhibits a good pharmacokinetic character with metabolic stability.
Products | Products > Disease Areas > Others | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Others | Products > Signaling Pathways > Fc Receptor (FcR)
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