PROTAC TEAD degrader-1

Overview

PROTAC TEAD degrader-1 is a TEAD2 degrader and antiproliferative agent with selective activity toward TEAD2 relative to other TEAD family members. PROTAC TEAD degrader-1 relies on CRBN and the proteasome system for TEAD2 degradation; disruption of CRBN binding attenuates this activity. PROTAC TEAD degrader-1 decreases expression of YAP target genes CYR61 and CTGF . PROTAC TEAD degrader-1 can be used for the research of NF2 -deficient cancer . (Pink: TEAD2 ligand ( HY-158400 ); Blue: Cereblon ligand ( HY-W087383 ); Black: linker ( HY-W008474 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > YAP

Product Information

• Catalog No.: HY-158342
• CAS No.: 3061498-57-2
• Molecular Formula: C44H41F3N6O7
• Molecular Weight: 822.83
• Purity: 99.82%
• Storage: 4°C, protect from light, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
• Availability: In-stock

Source

Original product source