NZ-66

Overview

NZ-66 is a ULK1 -Recruiting Chimera (ULKREC) and heterobifunctional chimeric molecule composed of a BL-918-derived ULK1 agonist linked to a mitochondrial outer membrane-targeting TSPO ligand via a six-carbon hexane linker. NZ-66 is a mitophagy inducer recruits ULK1 to mitochondria to induce ULK1 -dependent mitophagy , enhanced by mitochondrial insult, independently of the PRKN / PINK axis. NZ-66 can be used for the research of parkinson’s disease.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Parkinson's Disease | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > ULK | Products > Signaling Pathways > Mitophagy | Products > Signaling Pathways > TSPO

Product Information

• Catalog No.: HY-158408
• CAS No.: 3062992-25-7
• Molecular Formula: C48H40F8N8O5
• Molecular Weight: 960.87
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source