Pan-RAS-IN-2

Overview

Pan-rasin-2 (compound 6A) is an orally active molecular glues that targets RAS . Pan-RAS-IN-2 inhibits pERK ( IC 50 in AsPC-1 cells: 0.3 nM). Pan-rasin-2 has significant inhibitory activity on cell proliferation of RAS mutant cell lines. Pan-rasin-2 can form ternary complexes with cyclophilin A (CYPA) and RAS (ON) proteins and the formation of ternary complexes can block the binding of RAF downstream of RAS , which has anti-tumor (such as colorectal cancer , pancreatic cancer ) effects.

Application

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Product Information

• Catalog No.: HY-158409
• CAS No.: 3034673-92-9
• Molecular Formula: C46H60N8O5S
• Molecular Weight: 837.08
• Purity: 99.74%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (2.99 mM); Clear solution
• Availability: In-stock

Source

Original product source