2-APQC

Overview

2-APQC is an orally active and selective agonist of Sirtuin-3 ( SIRT3 ) ( K d =2.756 μM), antagonizes Isoproterenol/ISO ( HY-B0468 )-induced cytotoxicity. 2-APQC activates the SIRT3-PYCR1 axis to enhance mitochondrial proline metabolism and inhibit the ROS-p38MAP K pathway by inhibiting signaling pathways such as mTOR-p70S6K , JNK , and TGF-β/Smad3 . 2-APQC also activates the AMPK-Parkin axis to alleviate myocardial hypertrophy and fibrosis and protect cardiac function. 2-APQC can be used in the study of heart failure.

Application

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Product Information

• Catalog No.: HY-158426
• CAS No.: 500271-63-6
• Molecular Formula: C23H24FN5O
• Molecular Weight: 405.47
• Purity: 99.70%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (6.17 mM); Clear solution
• Availability: In-stock

Source

Original product source