PROTAC BcI-2/BcI-xI Degrader-1

Overview

PROTAC Bcl-2/Bcl-xL Degrader-1 is a Bcl-2/Bcl-xL PROTAC degrader with a DC 50 of 11.28 nM against Bcl-xL . PROTAC Bcl-2/Bcl-xL Degrader-1 promotes ubiquitination and degradation of Bcl-2/Bcl-xL. It exhibits anticancer activity against acute lymphoblastic leukemia. PROTAC Bcl-2/Bcl-xL Degrader-1 can be used in the research of BCL-2 -mediated or BCL-2-dependent diseases. (Pink: Bcl-2 and Bcl-xL ligand ( HY-158677 ); Blue: VHL ligand ( HY-158678 ); Black: linker ( HY-Y1139 )).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Bcl-2 Family

Product Information

• Catalog No.: HY-158551
• CAS No.: 3034200-49-9
• Molecular Formula: C78H94ClF3N10O12S4
• Molecular Weight: 1584.35
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source