TG11-77 hydrochloride is a potent, selective, orally active and brain permeant EP2 antagonist, with a K B of 9.7 nM. TG11-77 hydrochloride inhibits PGE2-induced human EP2 receptor activation. TG11-77 hydrochloride exhibits anti-inflammatory activity. TG11-77 hydrochloride reduces delayed mortality and memory deficit.
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