GE1111

Overview

GE1111 is a MRGPRX2 antagonist ( IC 50 = 9.4 μM). GE1111 inhibits MRGPRX2 / MRGPRB2 -mediated mast cell activation. GE1111 reduces the expressions of TSLP , IL-13 , MCP-1 , TNF-α , IL-1β and periostin , maintains the expression levels of claudin 1 and involucrin , restores the phagocytic activity of macrophages, and attenuates the activation of STIM1 and phosphorylated AKT . GE1111 exerts anti-inflammatory and anti-allergic effects in multiple animal models. GE1111 is applicable to the research related to rosacea, atopic dermatitis and ulcerative colitis.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Peptic Ulcer Disease | Products > Disease Areas > Ulcerative Colitis | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > TNF Receptor | Products > Signaling Pathways > Akt | Products > Signaling Pathways > ERK | Products > Signaling Pathways > Mas-related G-protein-coupled Receptor (MRGPR) | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-158990
• CAS No.: 2883669-12-1
• Molecular Formula: C28H22N2O5
• Molecular Weight: 466.48
• Purity: 95.73%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (10.72 mM); Clear solution
• Availability: In-stock

Source

Original product source