I1421

Overview

I1421 is an activator of the cystic fibrosis transmembrane conductance regulator ( CFTR ) with an EC50 of 64 nM for WT CFTR currents. I1421 also allosterically activates multiple mutants causing cystic fibrosis (CF) with good in vivo potency, with an oral bioavailability of 60% in mice corresponding to a half-life of 75 min. I1421 synergizes with Elexacaftor ( HY-111772 ) to enhance CFTR currents.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > CFTR

Product Information

• Catalog No.: HY-158991
• CAS No.: 3054995-92-2
• Molecular Formula: C18H18FN3O3
• Molecular Weight: 343.35
• Purity: 99.15%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (7.28 mM); Clear solution
• Availability: In-stock

Source

Original product source