WIZ degrader 9

Overview

WIZ degrader 9 is an orally active molecular glue degrader of the WIZ transcription factor. As a molecular glue , WIZ degrader 9 recruits WIZ to the cereblon E3 ubiquitin ligase complex via its ZF7 domain, driving proteasome-dependent degradation of WIZ . WIZ degrader 9 induces hemoglobin production, reduces the level of H3K9 dimethylation across the whole genome and at the β-globin locus, upregulates the transcription of γ-globin and BGLT3 , and increases the level of histone H3K9 acetylation in the promoter region of HBG1/2 . WIZ degrader 9 effectively induces fetal hemoglobin production in both mice and cynomolgus monkeys. WIZ degrader 9 can be used for research on sickle cell disease.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Molecular Glues | Products > Signaling Pathways > Histone Acetyltransferase

Product Information

• Catalog No.: HY-159099
• CAS No.: 2654011-51-3
• Molecular Formula: C21H27N3O4
• Molecular Weight: 385.46
• Purity: 99.29%
• Storage: 4°C, protect from light, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
• Solubility: ≥ 2.5 mg/mL (6.49 mM); Clear solution
• Availability: In-stock

Source

Original product source