PQM-164 (Compound 3e) has antioxidant activity (IC 50 : 0.93 μM for DPPH radical). PQM-164 shows anti-inflammatory activity against 6-OHDA ( HY-B1081A )-induced neuronal damage in activated microglial cells. PQM-164 decreases the accumulation of α-synuclein . PQM-164 promotes nuclear translocation of Nrf2 and its transcriptional activity. PQM-164 can be used for research of Parkinson’s disease.
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