XD2-149

Overview

XD2-149 is a ZFP91 PROTAC degrader with DC 50 values of 0.08 μM and 0.06 μM, respectively. ZFP91 is a bifunctional nuclear protein with both transcription factor and E3 ubiquitin ligase activities, and is classified as an oncogenic non-canonical NF-κB pathway regulator in tumor and immune regulation. XD2-149 induces proteasome-dependent degradation of the E3 ubiquitin-protein ligase ZFP91 . XD2-149 inhibits the STAT3 signaling pathway in pancreatic cancer cells and induces NQO1 -dependent cell death independent of ZFP91 degradation. XD2-149 can be used for the research of pancreatic cancer . (Pink: STAT3 ligand ( HY-13919 ); Blue: Cereblon ligand ( HY-14658 ); Black: linker ( HY-159572 )).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Pancreatic Cancer | Products > Disease Areas > Digestive System Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > STAT | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Quinone Reductase | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Zinc Finger Protein

Product Information

• Catalog No.: HY-159570
• CAS No.: 2710221-08-0
• Molecular Formula: C38H39N5O8
• Molecular Weight: 693.74
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source