BMS-986397

Overview

BMS-986397 is a potent, selective, and orally active cereblon-based molecular glue degrader of casein kinase 1α ( CK1α ). BMS-986397 induces apoptosis and cell cycle arrest in acute myeloid leukemia (AML) cells. BMS-986397 is a promising agent for the investigation of AML and high-risk myelodysplastic syndromes (HR-MDS).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Digestive System Inflammation | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > MDM-2/p53 | Products > Signaling Pathways > Molecular Glues | Products > Signaling Pathways > Ligands for E3 Ligase | Products > Signaling Pathways > Casein Kinase | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-159646
• CAS No.: 2564486-44-6
• Molecular Formula: C21H16ClF3N4O4
• Molecular Weight: 480.82
• Purity: 99.76%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (10.40 mM); Clear solution
• Availability: In-stock

Source

Original product source