(1S,2S,3R)-PLX-4545

Overview

(1S,2S,3R)-PLX-4545 is the (1S,2S,3R) enantiomer of PLX-4545 ( HY-159647 ). PLX-4545 is an orally active and selective cereblon-based molecular glue degrader of IKZF2 (zinc finger transcription factor Helios). PLX-4545 can reprogram immunosuppressive regulatory T cells into pro-inflammatory effector T cells, thereby enhancing anti-tumor immune responses.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > Molecular Glues | Products > Signaling Pathways > IKZF Family

Product Information

• Catalog No.: HY-159647B
• CAS No.: 2892066-42-9
• Molecular Formula: C28H31N3O4
• Molecular Weight: 473.56
• Purity: 91.78%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source