VL-422

Overview

VL-422 is an ionizable cationic lipid . VL-422 delivers CRISPR complementary single-guide RNA (sgRNA) and Cas9 mRNA to enable in vitro and in vivo gene editing. LNPs containing VL-422 loaded with Cas9 mRNA and sgRNA targeting the ANGPTL3 gene induce the deletion of premature stop codons within the ANGPTL3 gene in the liver of cynomolgus monkeys. Loss-of-function of ANGPTL3 leads to decreased levels of LDL, HDL and cholesterol in plasma. The VL-422 delivery system can be used for the research of gene editing strategies targeting lipid metabolism diseases.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Lipid Metabolism | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > Liposome

Product Information

• Catalog No.: HY-159709
• CAS No.: 2765519-47-7
• Molecular Formula: C62H117NO11
• Molecular Weight: 1052.59
• Purity: 96.90%
• Storage: Solution, -20°C, 2 years
• Availability: In-stock

Source

Original product source