Ulacamten

Overview

Ulacamten (CK-4021586; CK-586) is an orally active cardiac myosin inhibitor and an inhibitor of the double-headed cardiac heavy meromyosin ( HMM ) ATP ase (excluding single-headed myosin subfragment-1), with an EC 50 of 2.9 μM. Ulacamten regulates cardiac myosin , reduces excessive myocardial contractility, and alleviates left ventricular outflow tract obstruction. Ulacamten increases the left ventricular short-axis systolic internal diameter, inhibits dobutamine-induced exacerbation of obstruction, and exerts only a mild reducing effect on left ventricular systolic function. Ulacamten also inhibits the fractional shortening of the short axis without altering calcium transients. Ulacamten shows good safety and tolerability in purpose-bred cats with naturally occurring obstructive hypertrophic cardiomyopathy.

Application

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Product Information

• Catalog No.: HY-159821
• CAS No.: 2830607-59-3
• Molecular Formula: C21H25F2N3O3
• Molecular Weight: 405.44
• Purity: 99.22%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source