DHFR-IN-22

Overview

DHFR-IN-22 (Compound 8) is a DHFR ( Dihydrofolate Reductase ) inhibitor belonging to the class of 2,4-diaminopyrimidine compounds. DHFR-IN-22 exhibits significant inhibitory activity against purified DHFR enzyme and major species of nontuberculous mycobacteria (NTM), namely Mycobacterium avium and Mycobacterium abscessus . It shows an IC 50 of 1.1 nM and MIC of 1.5 μg/mL against M. abscessus , and an IC 50 of 6.3 nM and MIC of 0.1 μg/mL against M. avium . Additionally, it demonstrates an IC 50 of 2100 nM against human DHFR . DHFR-IN-22 holds potential for studying novel strategies to combat NTM infections.

Application

Products | Products > Disease Areas > Infection | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Bacterial | Products > Signaling Pathways > Antibiotic | Products > Signaling Pathways > Dihydrofolate reductase (DHFR)

Product Information

• Catalog No.: HY-159899
• CAS No.: 2941327-87-1
• Molecular Formula: C22H30N4O4
• Molecular Weight: 414.50
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source