5-HT 7 R antagonist 3 (Compound 6.4) is a selective 5-HT 7 R antagonist ( K i : 8 nM), with K i of 511 nM ( D 2 ), 8930 nM ( 5-HT 1A ) and 5786 nM ( 5-HT 2A ), respectively. 5-HT 7 R antagonist 3 possesses antidepressant and anxiolytic effects in mice.
Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > 5-HT Receptor | Products > Signaling Pathways > Dopamine Receptor
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