(-)-U-50488 hydrochloride

Overview

(-)-U-50488 hydrochloride ((-)-Trans-(1S,2S)-U-50488 hydrochloride) is a selective kappa-opioid receptor (KOR) agonist ( K d =2.2 nM) over μ-opioid receptor (MOR) ( K d =430 nM). (-)-U-50488 hydrochloride is a more active enantiomer than (+) trans-(1R,2R) U-50488 ( HY-15997A ) or the (±) trans-racemic mixture U-50488 ( HY-15997B ). (-)-U-50488 hydrochloride has a potent and sustained anti- HIV effect in fected blood monocyte-derived macrophages (MDM).

Application

Products | Products > Disease Areas > Lung Cancer | Products > Disease Areas > HIV-1 Infection | Products > Disease Areas > Cancer | Products > Disease Areas > Infection | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > HIV Infection | Products > Disease Areas > Sexually Transmitted Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Infection | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Opioid Receptor

Product Information

• Catalog No.: HY-15997
• CAS No.: 114528-79-9
• Molecular Formula: C19H27Cl3N2O
• Molecular Weight: 405.79
• Purity: 98.95%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: ≥ 2.5 mg/mL (6.16 mM); Clear solution
• Availability: In-stock

Source

Original product source