Dealanylascamycin (AT-265) (Compound 2) is a nucleoside antibiotic . AT 265 is a carbonic anhydrase ( CA ) inhibitor, with K i values of 167, 65.2, 234, and 143 nM for hCA I , hCA II , hCA IV , and hCA IX respectively. Dealanylascamycin is the active form of Ascamycin ( HY-121071 ). Dealanylascamycin exhibits broad-spectrum antibacterial activity and is effective against pathogenic bacteria such as Xanthomonas citri (MIC = 0.4 μg/mL). Dealanylascamycin has high cytotoxicity.
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