iPAF1C

Overview

iPAF1C is a inhibitor of the polymerase-associated factor 1 complex ( PAF1C ) with specific targeting to the PAF1 binding groove of CTR9 (a key subunit of PAF1C). iPAF1C disrupts PAF1C assembly by interfering with the PAF1-CTR9 interaction. iPAF1C selectively impairs BRD4-mediated recruitment of PAF1 to chromatin at hypoxia-responsive genes and inhibits RNA polymerase II (RNAPII) pause release. iPAF1C increases the population of HIV-1 NL4.3 Nef-IRES-GFP infected primary human CD4 + T cells in a dose-dependent manner. PAF1C can be used for the study of infection and diseases associated with abnormal hypoxic adaptation (e.g., cancers, neurological disorders).

Application

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Product Information

• Catalog No.: HY-160267
• CAS No.: 950403-60-8
• Molecular Formula: C27H26BrFN4O
• Molecular Weight: 521.42
• Purity: 99.59%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (9.59 mM); Clear solution
• Availability: In-stock

Source

Original product source