WD6305

Overview

WD6305 is a potent and selective METTL3-METTL14 PROTAC degrader. WD6305 has DC 50 values of 140 nM and 194 nM for METTL3 and METTL14 , respectively. WD6305 inhibits m 6 A modification and proliferation of AML cells, and induces apoptosis . (Pink: METTL3 ligand ( HY-115717 ); Blue: VHL ligand ( HY-150803 ); Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > METTL3

Product Information

• Catalog No.: HY-160415
• CAS No.: 3066823-45-5
• Molecular Formula: C61H75F2N11O5S
• Molecular Weight: 1112.38
• Purity: 98.98%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source