8(9)-EET

Overview

8(9)-EET is one of the main metabolites produced by the metabolism of arachidonic acid ( HY-109590 ) through the cytochrome P450 epoxide pathway. 8(9)-EET is an effective substrate for COX-1 and COX-2 . 8(9)-EET activates PPARα in HEK293 cells and inhibits the activity of NF-κB induced by IL-1β in a PPARα-dependent and -independent manner. The (8S,9R)-isomer of 8(9)-EET ([(8S,9R)-EET]) causes vasoconstriction, thereby reducing renal plasma flow and glomerular filtration rate.

Application

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Product Information

• Catalog No.: HY-160431
• CAS No.: 82864-43-5
• Molecular Formula: C20H32O3
• Molecular Weight: 320.47
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source