INY-05-040

Overview

INY-05-040 is an AKT degrader that can selectively and quickly degrade all three AKT isoforms. INY-05-040 exhibits anti-cancer activity. INY-05-040 can inhibit downstream signaling and cell proliferation in 288 cancer cell lines. INY-05-040 can suppress AKT signaling and induces the stress mitogen-activated protein kinase ( MAPK ) c-Jun N-terminal kinase ( JNK ). INY-05-040 is effective for breast cancer lines with a low-baseline activation of stress MAPK pathway. INY-05-040 can be studied for anti-cancer research. (Pink: Akt ligand ( HY-130988 ); Blue: VHL ligand ( HY-112078 ); Black: linker ( HY-W009413 )).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Breast Cancer | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > PROTAC | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Akt | Products > Signaling Pathways > PROTACs

Product Information

• Catalog No.: HY-160469
• CAS No.: 2503018-29-7
• Molecular Formula: C55H76ClN9O6S
• Molecular Weight: 1026.77
• Purity: 98.54%
• Storage: -20°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Availability: In-stock

Source

Original product source